In the past, we have demonstrated memory devices with polymer films embedded with nanoparticles and donor/acceptor molecules.
In addition, in a discontinuous model the OVA-specific CD8+ T cells could be recalled on re-exposure to OVA, demonstrating memory.
Since in the demonstrated memory devices there are three barriers (HfO2, Al2O3, and interfacial SiO2) that the electron must tunnel through to leak-out, the total transmission probability is thus found by multiplying the transmission probabilities through each oxide and total T is found equal to ~2 × 10−23 for the memory with graphene nanoplatelets.
Another group has also demonstrated memory loss and degeneration associated with loss of both presenilins in the mouse brain, once again, in the absence of Aβ generation [46].
Studies have demonstrated memory deficits in PDD (Higginson et al., 2005; Kuzis et al., 1999; Noe et al., 2004; Owen et al., 1993b; Varanese et al., 2010).
Rats in the sham group had discrimination indices significantly greater than chance (t(6) = 7.255, P < 0.001) demonstrating memory for the familiar object-context associations.
In addition, they raise the recent Liu et al (2012) study that demonstrated memory "reactivation" in the DG could drive fear behavior in a neutral context.
Rats in the novel OCR group (Fig. 1A; top row) explored the novel configurations of objects and contexts in preference to previously experienced configurations and thus demonstrated memory for object-context associations (t(7) = 8.714, P < 0.001; Figs. 1B,C).
Consistent with previous work (Dix and Aggleton, 1999; Mumby et al., 2002a; Eacott and Norman, 2004) it was shown that rats will explore novel object-context combinations in preference to familiar combinations, demonstrating memory for previously encountered object-context associations.
We wanted to examine whether the increased LEC activation in rats demonstrating memory for object-context associations, as suggested by increased c-fos expression, is a critical mechanism for remembering objects in context.
