Sentence examples for demonstrates linkage from inspiring English sources

The valine to isoleucine substitution at codon 64 in the chemokine co-receptor 2b gene (CCR2-V64I) demonstrates linkage disequilibrium with the CCR5 promoter region [ 44] and is common in populations of African ancestry [ 44- 46].

The 3′ polymorphisms are Apa 1 (Faraco et al, 1989) and Bsm 1 (Morrison et al, 1992) in intron 8, Taq 1(Morrison et al, 1992) in a silent site in exon 9 and a length polymorphism of a polyadenyl (polyA) microsatellite in the 3′-untranslated region (Ingles et al, 1997b), classified into long (L) and short (S) variants (L demonstrates linkage disequilibrium with b, a, T).

The demonstrated linkage of driving pressure to outcome [5] indicates that CRS, the quotient of tidal volume and driving pressure, is a reasonable and clinically accessible variable to be optimized during PEEP titration.

Only a linear form of this instability is needed to infer a relationship between PSSR and bottomside ESF (e.g., Dungey, 1956; Farley et al. 1970), but computer simulations that are based on nonlinear formulations of the instability were needed to demonstrate linkage between PSSR and EPBs in the topside F layer (e.g., Scannapieco and Ossakow, 1976; Zalesak and Ossakow, 1980; Zalesak et al. 1982).

Figure 1 shows the location of 2368 genes (out of 5067 total) that demonstrate linkage at a false discovery rate (FDR) ≤0.05 (see Text S1).

1) Genetic data demonstrated linkage of the CysC gene (CST3) with an increased risk of developing late-onset AD (for review [3], [45]).

Moreover, while each of the linkage studies has shown more allele sharing among affected individuals than would be expected by chance alone [4], none of them has succeeded in demonstrating linkage with MS at a genome-wide significance level.

We analyzed the linkage data both collectively (as previously published in [17]) and familywise and it became clear to us from this analysis, where we demonstrate linkage to five different chromosomal regions, that GERD is a disease with many different genetic predispositions.

Aligning our exome sequences with v7.1 scaffolds, we demonstrated linkage to chromosome 10, consistent with our previous mapping.

Independently, a large five-generation Basque family with similar dominant partial epilepsy also demonstrated linkage to chromosome 10q (Poza et al., 1999).

Adding to the challenge of disease gene discovery is the scale of genotyping that is required to conduct association studies in regions demonstrating linkage.