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Importantly, dogs were protected at both one and two years post-immunization, demonstrating durable protective immunity.
Human clinical gene therapy trials with AAV have demonstrated durable expression at therapeutic levels when targeting tissues like the liver2,3,4,5,6,7, motor neurons8, and the retina9.
Lopinavir (LPV -ritonavir has demonstrated durabLPV -ritonavirctivity in hasan immunodemonstratedirus type 1 (HIV-1)-infectedurableetrovirantiviralactivityease inhumanor (Pimmunodeficiencyatients.
After longer follow-up, enzalutamide continued to demonstrate durable tumor responses.
Studies with exenatide have demonstrated durable glycemic control for 3 years (84, 93).
In conclusion, I-tositumomab RIT demonstrated durable responses especially in those patients who achieved a complete response.
Follow-up analysis of IRIS trial participants continues to demonstrate durable responses for imatinib at 400 mg/day.
Two patients with FL demonstrated durable stable disease after six cycles with a PFS of 24 and 21 months, respectively.
However, some patients who progressed after discontinuation of anti PD-1 theranti PD-1demonstherapydurable responses after retreatment 47.
A phase I study of sorafenib and bevacizumab demonstrated durable partial disease responses (4 22+ months) in 6 of 13 ovarian cancer patients recruited.
The fly in this ointment is Windgassen's substitute: Hans Beirer, Vienna's durable utility heldentenor.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com