Sentence examples for demonstrates defective from inspiring English sources

Earlier work with tumor-infiltrating T cells from CLL patients demonstrates defective immunological synapse formation with antigen presenting cells together with reduced tyrosine-phosphorylated proteins at the synapse [ 52].

These data are further supported by published data showing that the sequences of polyadenylated U1 snRNAs generated following depletion of INTS9 extend beyond their normal termination sites, which demonstrates defective termination.

In conclusion, this study demonstrates defective trafficking of AQP2-R254W protoin thethe cell surface by disabled AQP2-R254W intorporation into subapical vesicles as well as impaired phosphorylation at S256, rendering the AQP2-R254W predominantlyminantoy to be localized in intracellular vesicles likely different from late endosomes.

In the liver, there was a concomitant reduced expression of glucose-6-phosphatase mRNA and glucose production from pyruvate (pyruvate tolerance test), demonstrating defective hepatic gluconeogenesis as a cause for the T. cruzi-induced hypoglycemia, despite reduced insulin, but elevated glucagon levels.

Using gene-targeted mice deficient in RhoH, we have previously demonstrated defective thymocyte development, positive and negative selection and TCR signaling.

We previously reported that Rhoh-/ T cells demonstrate defective CD3ζ phosphorylation and ZAP-70 recruitment to the TCR complex which results in the impaired TCR signaling and T cell development[3].

Two ACE chimeras were generated by substituting regions of the C domain with corresponding N domain sequences which also demonstrated defective intracellular processing, were enzymatically inactive, and did not localize to the cell surface [42].

We could also demonstrate defective mycobacterial association with Clecsf8−/− thioglycollate-elicited macrophages and neutrophils in vitro.

Without SCFβTrCP, T cells demonstrate defective IκBα degradation and reduced NFκB activation [ 14].

Patients with SLE demonstrate defective clearance of apoptotic cells, which evokes a secondary transition into necrotic cell death [ 10].

Mcm2-7 was initially identified during a genetic screen for S. cerevisiae mutants that demonstrated defective plasmid segregation (minichromosome maintenance [ 12]).