Resorbable calcium phosphate (CaP) biomaterials have demonstrated considerable efficacy in bone reconstructive surgery.
Cognitive behavioral therapy for insomnia (CBTi) has demonstrated considerable efficacy within randomized clinical trials and case-series designs.
Since then, anti-highway movements and pro-cycling advocacy have demonstrated considerable efficacy (Buehler & Pucher, 2017; Fackler, 2009; Harcourt, Rossiter, & Cameron, 2007; Hovey, 1998; Ladd, 2008; Mohl, 2012; Sewell, 1993).
Existing product candidates have demonstrated considerable efficacy in experimental animal models and in clinical trial subjects; however, severe adverse safety signals that appeared in recent phase II and phase III clinical trials involving certain HBOCs have in part hindered further development and licensing.
Ixabepilone has demonstrated considerable efficacy in MBC patients, even in those who are heavily pretreated and whose lesions have progressed after treatment with multiple therapeutic agents.
All of these agents have demonstrated considerable efficacy in placebo controlled randomized controlled trials (RCTs) in patients who have had an inadequate response to conventional Disease Modifying Anti-Rheumatic Drugs (DMARDs) such as methotrexate (MTX) or sulphasalazine.
This method demonstrates considerable potential for ultrasensitive SERS immunoassay applications.
For the licensed indication, a significant efficacy was reported in the Winblad analysis, although the authors highlight that interpretation of the results is limited because the LOCF analysis demonstrates considerable heterogeneity.
In conclusion, the results of this study demonstrated considerable agreement between changes in clinical endpoints used to evaluate efficacy in RA RCTs and PROs of physical function, HRQoL and fatigue.
Owing to their molecular differences, these agents demonstrate considerable variation in their pharmacokinetic and pharmacodynamic properties, which are likely to affect clinical efficacy [ 70].
Vancomycin-susceptible clinical MRSA isolates demonstrate considerable heterogeneity in vitro with respect to vancomycin MIC and vancomycin killing, affecting the clinical efficacy of the drug.
