Wounds made on murine or grafted human skin demonstrated accelerated healing when the animals were IV injected with gene-corrected DEB fibroblasts.
Although cutaneous and mucosal wound healing proceed through the same stages of hemostasis, inflammation, proliferation, and remodeling, mucosal wounds demonstrate accelerated healing compared to cutaneous wounds [ 1- 4].
A subsequent study by the same group using a heparin-/fibrin-based TGF- β3 delivery system to the tendon-to-bone insertion demonstrated accelerated healing with increased inflammation, cellularity, vascularity, and cell proliferation at early time points [ 29].
Tat-Smad7 treated mice show accelerated healing compared to the control group.
Two recent studies demonstrated that TGF-β3 may accelerate healing [ 80, 87].
Furthermore, it has been reported that bFGF can exert a significant effect on the cell proliferation of human dental pulp stem cell isolated by immunomagnetic bead selection method for STRO-1 and that among the cytokines and growth factors, bFGF is clinically proven, having demonstrated accelerated acute and chronic wound healing [ 26].
Oral mucosa is composed of highly-regenerative stratified epithelium and submucosal connective tissue, which demonstrate accelerated epithelial turnover and scarless wound healing when compared with epidermis.
These changes have aimed to increase bone-implant surface connectivity and accelerate healing.
While the majority heal uneventfully, certain sub-groups would benefit from strategies to accelerate healing.
Indeed, accelerated healing of gastric ulcers has been demonstrated in rats treated with a nitric oxide-releasing derivative of diclofenac, and a similar effect could be observed by treating the rats with glyceryl trinitrate [21].
The treatment, the researchers found, "accelerated healing significantly".
