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Previous Ottman and Lipton's studies on 1948 patients with epilepsy demonstrated a twofold higher risk for migraine in patients with epilepsy compared to their first degree relatives without epilepsy, and they also showed a nearly twofold risk of migraine compared to controls (24%% vs 12%%).
GLC4/ADR cells, however, demonstrated a twofold lower topoisomerase I activity than GLC4 cells.
Dramatically, at e13.5, Foxc1 −/− mutants demonstrated a twofold reduction of ventricular zone proliferation, compared to e13.5 wild-type animals.
Rothman (1974) demonstrated an important implication of RDA for this situation in an interesting thought experiment.
Titration experiments in extracts demonstrated that a twofold increase in Wee1 activity is sufficient to cause the delay in mitotic entry seen in Mos-treated extracts.
α(2)M*-treated cells demonstrate about a twofold increase in mTORC2 kinase activity as determined by kinase assay of Akt(S473) phosphorylation and levels of p-Akt(S473) in mTOR and Rictor immunoprecipitates.
FSH-CTP consistently demonstrated about a twofold improvement in half-life over recombinant FSH, no matter whether it was dosed subcutaneously or intravenously [ 33, 112].
Our analysis has clinical implications as it demonstrates a lack of testing for specific gastrointestinal pathogens.
Levels of its mRNA demonstrated a statistically insignificant twofold increase at 4 hours.
The higher affinity FCGR3A-158V allele was associated with an increased susceptibility to RA, with homozygotes demonstrating a 1.5-fold to twofold increased risk for RA and a twofold to fourfold increase in nodules [ 11, 12].
The results demonstrate a misalignment of frames with implications for further development of the NP role.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com