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The MS culture system demonstrates a small subset of DCIS cells with self-renewal clonogenic capacity showing 1.5 ± 0.1% MS forming efficiency (MFE), which is greater than normal breast MFE, 0.5 ± 0.1% (P < 0.0001).
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Our study demonstrates that a small subset of genes identifies leukemias with MLL-specific rearrangements and clearly separates acute leukemia samples according to lineage origin.
Our study demonstrated that a small subset of genes identifies MLL-specific rearrangements and clearly separates acute leukemia samples according to lineage origin.
Interestingly, it was demonstrated that a small subset of Areg+ Tregs in the spleen shared TCR sequences with both Areg-positive and -negative Tregs from muscle.
The use of different populations in the discovery phase may certainly yield different profiles, but our point was to demonstrate that a small subset of informative genes could provide a significantly prognostic score.
Analyses of microsatellite markers have demonstrated that a small subset of patients with very high ARs actually harbor a loss of heterozygosity (LOH) of the FLT3 gene at chr13q locus.
It has been demonstrated that a small subset of cancer cells with stem cell properties, referred to as 'cancer stem cells' (CSCs), survive intensive anticancer therapies better than proliferating progenitor cells or differentiated tumour cells (Dean et al, 2005).
By means of immunohistochemical techniques, we demonstrated that a small subset of cells in the lateral hypothalamus, and the perifornical and periventricular areas were orexin-A and orexin-B positive not only in 2-week-old and adult rats but also in 1-week-old animals.
Since the application of an alanine scanning mutagenesis (ASM) study to the growth hormone it was demonstrated that only a small subset of residues at a protein protein interface is essential for binding — the hot-spots (HS).
However, clinical trials demonstrate that only a small subset of osteosarcoma patients respond to IGF-1R antibodies [ 3].
Other experimental animal systems have demonstrated that only a small subset of metastatic cells (approximately 2%) survive and grow at secondary sites [ 34].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com