"Most of these events occurred during a period of time when GlaxoSmithKline was aware that the company's own research demonstrated a hazard for the drug, but they failed to warn physicians or patients".
The article quotes Dr. Steven Nissen of the Cleveland Clinic, speaking of Avandia, as saying that "GlaxoSmithKline was aware that the company's own research demonstrated a hazard for the drug, but they failed to warn physicians or patients".
Additionally an even more powerful relationship was seen in lone AF with a QTc interval ≥458 ms demonstrating a hazard ratio of 2.32.
Survival comparison of accelerated patients with matched controls treated with conventional fractionation demonstrated a hazard ratio of 1.13 (95% confidence interval 0.85-1.51; P = 0.39).
At a median of 68 months of follow up, the ATAC trial demonstrated a hazard ratio (HR) of 0.83 (95% confidence interval [CI] 0.73 0.94) for women with hormone receptor positive breast cancer treated with anastrozole [ 2].
Two retrospective cohort studies in the USA including respectively 118 533 haemodialysis patients surviving 2 years on haemodialysis and 36.966 patients surviving 1 year on haemodialysis demonstrated a hazard rate for mortality of 0.84 [ 30] to 0.94 [ 31] for pneumococcal vaccination alone and 0.71 [ 30] to 0.73 [ 31] for combined pneumococcal and flu vaccination.
Hand in hand with its 40th-anniversary Apollo barbecue, Draper Laboratory in Cambridge, MA, demonstrated a hazard-detection system for future lunar vehicles and showed off a mock-up of its collaborative project with MIT that will help land a small robotic vehicle on the moon.
Indeed, a pooled analysis of three randomized studies, performed on 34,701 elderly patients treated with etoricoxib or diclofenac for osteoarthritis/rheumatoid arthritis, demonstrated an hazard ratio of 1.98 (95% CI 1.45-2.71) for the occurrence of intestinal damage in patients aged over 65 years [ 22].
Within the univariate model, the non-PN classification demonstrates a high hazard ratio (Table 3: HR = 1.94, P-value = 3.15e-5 3.15e-5
This put the American government, hobbled by the need to demonstrate an "actual hazard" before acting, in an awkward position.
