In earlier studies, Laws et al. (Toxicol. Sci., 58, 366 376, 2000) demonstrated a delay in female rat sexual maturation induced by ATR, effects that could equally have been caused by inhibition of hypothalamic GnRH release.
Comparative pathogenesis studies demonstrated a delay in RB-C22v spread to, and decreased replication in the tonsils, a 102 to 107 log10 reduction in virus titers in lymphoid tissues and blood, and an overall delay in generalization of infection relative to BICv.
Animals receiving vaccines with the PkCSP and or PkSSP2 antigens demonstrated a delay in appearance of parasites in the blood, consistent with killing of sporozoites or infected liver cells and development of fewer liver schizonts [60].
In an open-label study design, the neurological deficits in 11 patients with the cerebellar type of MSA (MSA-C), who received consecutively intra-arterial and three repeated intravenous injections for three months, were compared with non-treated MSA patients, demonstrating a delay in progression of neurological deficits after MSC therapy [22].
Animals treated with anti-CCL20 antibodies demonstrated a delay in tumor appearance – in the control group on day 28, 100% of animals developed visible tumors, while in the anti-CCL20-treated group, only 60% appeared with tumors on the same day.
Our in vivo xenograft experiments demonstrated a delay in tumor progression when topotecan was combined with bortezomib.
Previous researches demonstrated a delay in the up-regulation of auxin-induced gene expression in a pPLAIIIδ loss-of-function mutant [ 8].
Triacylglycerol lipase demonstrated a delay in peak activation in the obese men, although the overall lipolytic response did not differ between the groups.
