Notably, control neutrophils incubated with serum taken from patients with diabetes also demonstrated a defect in phagocytosis, implying that the defect was, in fact, due to defective opsonisation and not to a deficit in neutrophil function per se: in other words, the defect is humoral.
Therefore, these lesions have fewer macrophages, including Kupffer cells, than normal liver tissue, and these lesions may demonstrate a defect in the Kupffer phase.
We will not pursue that dispute here except to note that even if the case is made that ID could not count as proper science, which is controversial,[24] that would not in itself demonstrate a defect in design arguments as such.
Interestingly, cells with mutant dyskerin activity also demonstrate a defect in translation of messenger RNAs containing IRES elements [42].
Strain 1F8 demonstrated a defect in melanization, showing much less pigment accumulation than wild type cells (Figure 4B).
The neurons that we analysed in neonate MGC might therefore have been too immature to demonstrate a defect in MHC regulation due to MeCP2 deficiency.
These mice demonstrated a defect in interneuron differentiation and survival, which is associated with functional deficits that may be similar to the subset of ATR-X patients with visual anomalies [9].
These analyses clearly demonstrate a defect in the pf16 male flagellum and its function (Figure 1 and "Videos S1 and S2"), which was reflected in the frequency of fertilization and zygote formation.
SDS-PAGE resolution of infected cell proteins that were radiolabeled with 35S-methionine during MVAΔudg (vDG014 -, MVA udg+ -, or mock-infection of CAN20 and DF-1 cells demonstrated a defect in the production of the protein products of several late genes during MVAΔudg-infection of non-complementing DF-1 cells (Figure 6).
