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Makino et al. [ 27] demonstrated upregulated preproET-1 mRNA in the aorta from STZ-induced diabetic rats.
In each of these cases, the cells in the invasive tumour demonstrated upregulated GLUT-1 as did the cells in the periphery of the DCIS immediately adjacent to the focus of microinvasion.
We demonstrated upregulated production of the entire NGAL molecule in neutrophils by GM-CSF.
In contrast, Real-Time PCR analyses utilizing primers spanning the TWEAK-binding (exon 1 2), transmembrane (exon 2 3, only present in full-length) and TRAF-binding cytosolic (exon 3 4) motifs of Fn14 demonstrated upregulated expression of full-length Fn14 (NM_013749.2) in RVs of mice after PAB (Fig. 1a).
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Furthermore, they demonstrate upregulated chemokine receptors relevant to atherosclerosis and high capacity of oxidized low-density lipoprotein-cholesterol (LDL-C) uptake.
Multicellular spheroids recapitulating ductal carcinoma in situ (DCIS) microenvironmental conditions demonstrate upregulated glucose transporter 1 (GLUT1) as adaptation to hypoxia followed by growth into normoxic regions in qualitative agreement with model predictions.
Nef-expressing T cells demonstrate upregulated Fas and FasL, decreased Bcl-2 and Bcl-XL expression, increased PD-1 expression, and undergo apoptosis by both caspase-dependent or -independent mechanisms.
In the IVD, Peng and colleagues demonstrated highly upregulated FGF2 and FGFR1 in painful degenerated human spine disc cells compared with normal cells [ 17].
Furthermore, the hybrid material was demonstrated to upregulate the steady-state-expression of the cell migration-inducing chemokine SDF-1α.
Although HIV gp120 has been demonstrated to upregulate T cell death in vitro, we were unable to find a direct correlation to this parameter in vivo in this model [16], [19], [21].
Additionally, the RGD peptide has been demonstrated to upregulate the expression of certain types of proteins [ 18].
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