Sentence examples for demonstrated trail from inspiring English sources

In vitro studies with FLT-MSCs demonsTRAILd TRAIL expression and antitumor effects on breast cancer cells.

A study in colon cancer cell lines [46] showed that the DAC inhibitor sodium butyrate also caused substantial decrease in c-FLIP protein concurrent with TRAIL sensitization, although similar studies in several hematological cell lines using sodium butyrate and vorinostat demonstrated TRAIL sensitization without reduction of c-FLIP [34].

An early report on the melanoma cell line, Mel-FH, demonstrated TRAIL-R1 as predominantly expressed in the nucleus, where it colocalized with TRAIL-R3 and TRAIL-R4.

One study demonstrated TRAIL-induced apoptosis of CD133-positive glioma cells (Sasportas et al, 2009), a second showed radioresistant oesophageal cancer cells were 10 times more susceptible to TRAIL therapy (Zhang et al, 2008) and a further study noted an increased sensitivity of colon cancer SP cells to recombinant TRAIL therapy (Sussman et al, 2007).

A good reason for complaining is if you want to take a case to court and use it to demonstrate an evidence trail whereby you followed the exact policies and procedures outlined by the company - who still did nothing.

In addition, conventional flow cytometry analysis demonstrated that TRAIL resistant MCF7 cells exhibited substantial levels of TRAIL-R4 expression but not TRAIL decoy receptor-3 (TRAIL-R3) on surface.

A recent report demonstrated that TRAIL resistance could be overcome by inhibition of CDK 9. Combining TRAIL with the CDK-interfering agent roscovitine revealed synergistic CI-values (CI5  μ M roscovitine=0.67, CI10  μ M roscovitine=0.48, CI15  μ M roscovitine=0.64).

As LSECs are constantly exposed to activated immune cells expressing death ligands and we previously demonstrated that TRAIL synergizes with paracetamol in liver toxicity, we here investigated the effects of TRAIL and paracetamol on LSEC death.

Studies in animals have shown that TRAIL mediates regression of cancer xenografts without affecting normal tissues, and human phase I studies have demonstrated that TRAIL agonists are safe [ 3, 6].

Although it has been demonstrated that TRAIL induces the extrinsic apoptosis pathway, several cancer cell lines are resistant to the proapoptotic effects of TRAIL.

The only way I can see this lawsuit finding any sort of legs is if a weakness is found in Microsoft's accounting practices — with a demonstrated paper trail — that the company deliberately avoided a charge to its Surface RT inventory to delay having to publicize its slow sales.