The model was validated against experimental pressure drop, demonstrating tolerable discrepancies.
The IDO regimen demonstrated a tolerable toxicity profile in the present trial.
The pharmacodynamic interactions demonstrated that the tolerable dose of bevacizumab used is half or less of the recommended dose in other solid tumour studies (Azad et al, 2008b).
PEP02 also demonstrated increased efficacy and tolerable toxicity when compared with free irinotecan in an orthotopic pancreatic cancer mouse model (Hann et al, 2007).
In a phase I study, neratinib was tolerable and demonstrated antitumor activity in patients with solid tumors, including 8 of 25 evaluable patients with erbB2-positive advanced breast cancer.
However, a target protein can be purposely driven to inclusion bodies, which demonstrate full cell tolerable activity.
The phase II clinical trial demonstrated potent antitumor activity and tolerable toxicity profile by mogamulizumab monotherapy (Ishida et al., 2012), which led to approval by the regulatory authority in Japan in 2012.
Recent studies and clinical trials have demonstrated the efficacy of tissue-tolerable plasma (TTP) in wound healing [ 13, 17].
In this study DEX was demonstrated to be a safe and tolerable drug with few side effects, especially related to the cardiovascular system.
Subsequent experience in 50 100 pain patients employing modern neurosurgical techniques was more favorable and demonstrated septal stimulation to be safe and tolerable.
