Sentence examples for demonstrated to normalize from inspiring English sources

Continuous intravenous administration of GLP-1 has been demonstrated to normalize blood glucose levels in diabetic subjects [ 95].

Antiangiogenic agents that disrupt the vascular endothelial growth factor pathway have been demonstrated to normalize tumor vasculature and improve tumor oxygenation in some studies and to induce hypoxia in others.

First, by using transgenic mice harboring transgenes for doxycycline-inducible RASAL1 overexpression, RASAL1 over-expression was demonstrated to normalize the increased intrinsic proliferative activity of fibrotic fibroblasts in these mice with unilateral ureteral obstruction.

The hormonal status of RUPP offspring may play a significant role, as castration of male RUPP offspring has been demonstrated to normalize BP [ 162], whereas ovarianectomy induced hypertension in otherwise normotensive female RUPP offspring [ 60].

In diabetic nephropathy several of these variables are abnormal, and RAAS blockade has been demonstrated to normalize directly measured or estimated glomerular hydraulic pressure (7– 9), to reduce the shunt-like defects in the membrane, at least in part (10), and to restore the charge-selectivity properties of the glomerular membrane (11).

This dose was aimed to achieve intravascular concentrations of GLP-1 within the infused forearm, similar to those previously demonstrated able to normalize plasma glucose levels in patients with type 2 diabetes (13), and to improve vascular response to vasodilators in the human forearm (9).

All data were normalized to GAPDH, which has been demonstrated to be stable even after peripheral nerve injury insult10.

CLA has also recently demonstrated an ability to normalize impaired glucose tolerance and improve hyperinsulinemia in a pre-diabetic animal model.

Furthermore, FDG-glucose analysis with microPET revealed that LXRα−/− mice demonstrated an inability to normalize the increases in glucose uptake levels achieved in pressure overload-induced hypertrophy (Fig 5I and J, Supplementary Fig S6).

The samples were normalized against an endogenous region that was demonstrated to bind CTCF with high affinity (23).

We show the general relevance of these biases across different datasets, when applicable, and demonstrate how failing to normalize for these biases can potentially lead to spurious conclusions.