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Performance of shielding of the High Temperature Engineering Test Reactor (HTTR) has been demonstrated to establish a design method for shielding of Very-High-Temperature Reactor (VHTR) as a Generation-IV nuclear energy system.
As the biochemical hallmark of programmed cell death is initiated by the caspase cascade that ultimately leads to DNA fragmentation, both caspase activation and DNA fragmentation need to be demonstrated to establish if a cell has undergone the process of apoptosis [ 11].
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The International Agency for Research on Cancer (IARC) has concluded that there is "sufficient" evidence for coal tar pitch (IARC 1998a) to be considered carcinogenic in humans, but that creosotes (IARC 1998b) have only "limited evidence" for human carcinogenicity, despite demonstrating "sufficient" evidence to establish carcinogenicity in animals.
Therapeutic delay is especially catastrophic in CTX, since there is a specific treatment (chenodeoxycolic acid), which is effective in reducing the plasma levels of cholestanol but has not been demonstrated to improve established neurological deficits.
The nematode has already been demonstrated to be an established model to study pathogenicity mechanisms of L. monocytogenes[ 23].
Bedside echocardiography is considered a promising tool for the management of critically ill patients [ 13], and has been demonstrated to be useful in establishing the diagnosis and provides hemodynamic monitoring [ 14- 16].
The public clearly consider a demonstrated commitment to establishing and maintaining a healthy lifestyle to be the most important prioritisation criterion.
It is normally assumed that medical practices are based on firm clinical evidence and that new practices or techniques are introduced when superiority, or at least non-inferiority, has been demonstrated compared to established treatments.
Besides, IgE nonspecifically binding to tumor cells has also been demonstrated to be a powerful adjuvant establishing tumor-specific immune memory [ 29, 30].
Total joint arthroplasty (TJA) of the knee (TKA) and ankle (TAA) are well established procedures demonstrated to provide good long-term results in terms of reduced pain and increased function [ 1, 2].
In animal model, anti-GEP monoclonal antibody (mAb) was demonstrated to inhibit the growth of established HCC, providing evidences that GEP is a potential therapeutic target for HCC (15).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com