Eculizumab has been demonstrated to block complement activation in the treatment of patients with paroxysmal nocturnal haemoglobinuria (PNH), in which red blood cells are lysed by complement due to an inherited lack of inhibitors on their cell surface, and is, therefore, approved for this application.
Only capsid proteins, 3CD, and 3D have been demonstrated to trans-complement (Novak and Kirkegaard, 1994; Nugent et al., 1999; Oh et al., 2009).
That the intracellular accumulation of lipofuscin in the GLC samples of our study occurred in a cellular system that we have already demonstrated to have a depleted complement of antioxidants [ 15] demonstrates the potential for such a phenomenon in vivo.
As the mechanism underlying Lm targeting into the CD8α+ DC has been recently demonstrated to depend on serum complement proteins and platelets (Edelson et al., 2011), such mechanistic studies are underway.
The complement system has been demonstrated to play a key role in the development of sepsis in rodents and humans [22], [23].
Recently a new approach called "DNA barcoding" [27], [28] emerged in the conservation and forensic community, demonstrating the need to complement classic taxonomy with other tools.
In the present work, using the castor bean genes, we obtained similar results with DGAT1, and were also unable to demonstrate DGAT2 ability to complement TAG synthesis compared to DGAT1, as previously described by Zhang and collaborator's using DGAT2 from Arabidopsis [ 70].
MBF1-type genes (SlER24 and StMBF1) encode functional transcriptional co-activators as demonstrated by their capacity to complement the yeast mbf1 mutant [ 6, 7].
In addition, we demonstrated that ApHMW1C is able to complement a deficiency of HMW1C and mediates HMW1 glycosylation and adhesive activity in whole bacteria.
These results demonstrate that mito81 210 is sufficient to complement endogenous frataxin functions and promote survival, providing the evidence that mature hFXN81 210 is the functional form for in vivo Fe-S cluster biosynthesis.
