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The meso-limbic and orbito-frontal dopaminergic systems has also been demonstrated to be implicated by simultaneously measuring the fixation potential of 11C-raclopride, a D2/D3 agonist.
Residues located at the key positions identified in this work, have been experimentally demonstrated to be implicated in ligand recognition in several systems, including, among many others, adenosine, serotonin, P2Y, and free fatty acid receptors [20], [28], [63] [66].
In addition, it has been demonstrated to be implicated in cancer invasion and metastasis [ 40- 42].
Among the 21 GyrB substitutions described in the literature, only two have been demonstrated to be implicated in resistance to FQ (N538D and E540V) [ 17].
On the basis of their expression patterns various serine and cysteine proteases and ribonucleases, have been demonstrated to be implicated in the control of xylem PCD [ 4, 29, 44- 47].
Other neurotrophic factors, such as HGF, VEGF, NGF, bFGF, FGF-2, and IGF-1, have been demonstrated to be implicated in endogenous repair mechanisms mediated by MSCs [ 126, 134, 137, 153, 154].
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DCLs have been demonstrated to be widely implicated in the processing of diverse sRNA precursors in plants (Chen, 2009).
Both these two domains have been demonstrated to be present in proteins implicated in plant resistance (Spoel and Dong 2012; Sekhwal et al. 2015).
MMP-9 has been demonstrated to be the main metalloproteinase implicated in the development of IBD [ 8, 14].
Although the role of Bcl-2 has been established as a key player in the control of apoptosis, recent experimental studies have demonstrated Bcl-2 to be implicated in regulating the cell cycle and proliferation [ 9].
Moreover, H3S10 was demonstrated to be a substrate for PIM1 kinase, implicated in regulation of 20% of c-Myc target genes and thereby contributing to their transcriptional activation, what further links this PTM of histone H3 to cellular transformation [61].
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