BTDS 20 treatment was demonstrated to be efficacious and generally well tolerated.
Nevertheless, none of these strategies demonstrated to be efficacious when translated to humans12, and there is still the need for alternative approaches and new targets to be identified.
Injection of botulinum toxin into the LES has also been demonstrated to be efficacious, although this needs to be repeated periodically and is generally reserved for elderly patients with comorbidities.
To date, there have been few interventions that have been demonstrated to be efficacious by multiple large, well-designed, multicenter randomized clinical trials.
Currently, several methods have been demonstrated to be efficacious with some children however no treatment completely ameliorates the symptoms of ASD or works for all children with the disorder.
Sporting practice for psychotic patients have been demonstrated to be efficacious as a rehabilitation tool at various levels, improving social interaction, self esteem, body self consciousness, reduce anxiety and depression, reduce stigma, improve compliance, reduce admission rates, reduce aggressiveness, reduce family burden.
Amiodarone has been demonstrated to be more efficacious than propafenone or sotalol in the Canadian Trial of Atrial Fibrillation.
Lithium was the most extensively studied compound and demonstrated to be an efficacious treatment in 32 cases.
In contrast, IVM demonstrated to be highly efficacious against Trichostrongylus spp. in abomasum and small intestine.
More recently ranitidine bismuth citrate (RBC) and two antibiotics has been demonstrated to be an efficacious first-line therapy [ 11- 14].
Concurrent chemoradiotherapy (CCRT) with or without adjuvant chemotherapy (AC) has been demonstrated to be most efficacious, and is now recommended as a standard treatment for patients with locoregionally advanced NPC [ 4, 5].
