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In support of this idea, proteins closely related to ankyrin and 4.1 have been purified from brain and have been demonstrated to associate with brain spectrin.
During the past few years, hepcidin and several iron metabolism related proteins have been demonstrated to associate with lung cancer genesis and tumor cell proliferation (Xiong et al., 2014).
Though the relationship between YAP/TEAD is the best understood, YAP has also been demonstrated to associate with additional DNA binding proteins during transcriptional activation, including SMAD family transcription factors [11].
Myosin Va was demonstrated to associate with the ER in mouse melanoma cells and transport ER vesicles in squid axons [16], [42].
Protein phosphatase 2A was demonstrated to associate with both Pak 1 and phospholamban.
SIKE was demonstrated to associate with IKKE and TBK1 by co-immunoprecipitation.
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A corresponding peptide (residues Lys158-Asp171, termed KKDC) was demonstrated to physically associate with heparin and HS, and to inhibit heparanase enzymatic activity.
For example, hyper-methylation in the promoter region typically represses a gene's transcription, and aberrant DNA methylation has been demonstrated to be associated with certain tumors2.
Angiogenesis also has been demonstrated to be associated with tumor progression, aggressiveness, and metastases.
On the other hand, the damage to the hippocampus has been demonstrated to be associated with not only a variety of neurological and psychiatric disorders, but also some physical diseases24,25.
Recently presented early phase clinical trials have shown encouraging activity of immune checkpoint blockade in treatment of SCLC patients42,43,44, and high TMB has been demonstrated to be associated with superior response and prolonged survival in SCLC45.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com