More recently, we have demonstrated stimulated production and secretion of cytokines, upon incubation of monocytes with inactive heparanase (Blich et al., in preparation), further illustrating the relevance of heparanase non-enzymatic functions to inflammatory processes and possibly GVHD.
A few drugs did demonstrate "stimulated reporting" trends.
Previous studies have demonstrated that stimulating the cutaneous plantar sensory receptors of the foot through textured insoles improves human balance and walking.
This was demonstrated by stimulating each receptor with rhTRAIL in combination with blocking antibodies, as well as by stimulating each receptor with agonistic antibodies only.
CNTs have been demonstrated to stimulate neuronal differentiation [6, 8]; however, CNTs are easily disintegrated without supporting matrices and require delicate handling and intensive labor.
Both increased coagulation and platelet activation have been demonstrated to stimulate tumor angiogenesis, as well as metastasis, and can therefore contribute to disease progression [11], [18].
Low GM3 levels relative to another ganglioside GD3 have been demonstrated to stimulate angiogenesis [ 15, 16].
We also applied different forms of stress, including ROS, which have been demonstrated to stimulate the formation of stress granules.
In addition, heavy metals have been demonstrated to stimulate formation of ROS in roots and leaves [ 7, 52].
Epidermal growth factor in combination with gastrin, insulin-like growth factor, transforming growth factor- β, and islet neogenesis-associated protein have been demonstrated to stimulate β-cell growth.
