Previous studies have demonstrated steep gradients of decreasing doxorubicin fluorescence with increasing distance from blood vessels, such that many tumor cells are not exposed to drug.
Only BCNU, melphalan, nitrogen mustard, and the combination of thiotepa and cyclophosphamide demonstrated steep dose-response relationships over a wide dose-range.
Furthermore, SNI excursions demonstrated a steeper increase in glucose levels and twice the amplitude of SWI excursions.
For GSTP1-105, individuals with the Ile allele present (i.e., zero or one of the variant Val allele) demonstrated a steeper regression slope for Ery-Hg.
Our experiments in murine hearts showed smaller APDs and VERPs at the RVOT than elsewhere and also demonstrated a steeper gradient of values in this region.
We found evidence of effect modification: individuals with zero or one variant allele demonstrated a steeper regression slope for Ery-Hg (p = 0.038) compared with individuals with two or more variant alleles.
We found that BNP kinetics differed significantly in the two subgroups of critical sepsis patients, as the BNP concentrations demonstrated significantly steeper declines in septic shock patients than in severe sepsis patients.
An effect modification was indicated for the combination of GCLC-129 and GSTP1-114 (Table 4), where subjects with zero or one variant allele demonstrated a steeper regression slope compared with individuals with two variant alleles.
The adults demonstrated the steepest learning curves.
Furthermore, our multivariable model demonstrated a steep rise in gradient of risk with each episode of AKI.
After 48 h exposure time, xanafide demonstrated a steep response curve in the four breast cell lines tested.
