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All six studies examining the effect of CDSS on antibiotic prescribing reported at least one positive outcome, however, four studies demonstrated significant impacts on the majority of outcomes.
Alternative treatments including α-interferon 2b and local hepatic therapies for isolated metastases, such as hepatic arterial bland or chemo-embolisation, resection and radiofrequency ablation, have not demonstrated significant impacts on overall survival (OS).
Cash transfers have demonstrated significant impacts on the human capital of children in many countries in Latin America and Asia, and evidence is building of such impacts from programmes in sub-Saharan Africa.
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Clinical trials have demonstrated significant impact in reducing weight and incidence of type 2 diabetes mellitus.
The STeLLA video-based PD (VbPD) program demonstrated significant impact, with high effect sizes, on elementary teachers' science teaching practice and their students' learning.
All discussed powders demonstrated significant impact on surface activity of Survanta solution, either positive or negative, depending on powders composition and concentration.
This yearlong, video-based, analysis-of-practice PD program demonstrated significant impact, with high effect sizes, on upper elementary teachers' science content knowledge, teachers' pedagogical content knowledge (PCK), teachers' science teaching practice, and, most importantly, on student learning (Fig. 1).
Some results need comments: we only demonstrated significant impact of RAS alterations in ADC and not in SQCC.
To the best of our knowledge, commonly used hypotensive drugs such as angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, and beta blockers have not demonstrated significant impact on neither QT interval nor sleep stages.
Furthermore, the magnitude and point in time of tumour response has demonstrated significant impact on prognosis, underlining the need for an intensive first line regimen inducing early tumour shrinkage [ 59].
The investigators found that a 20-week (10 contacts) cognitive behavioural intervention demonstrated significant impact on severity of cancer-related symptoms after four contacts (10 weeks), and this reduction was maintained at 20 weeks among those patients who entered the trial with moderate to severe symptoms.
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