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However, analysis of individual time points using PCA demonstrated separation between the different dose groups which was improved by using partial least squares (PLS) to regress metabolic profile against dose of PB (Q2 = 0.69, 0.54, 0.60, 1 component, for days 1, 3, and 14 respectively, Q2 = 0.60, 2 components, day 7; figure 2A, table 2).
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To demonstrate separation between endogenous DRαand transfected DRαV5 in DR-Ii complexes by an independent experimental approach, we transiently expressed DRαV5, DRα, DRβ, and Ii simultaneously in COS-7 cells (Fig. 6C).
Linear discriminant analysis demonstrates separation between different categories such as histological types.
As expected, individual continental PCoA analyses demonstrate separation between East and West African samples (Supplementary Fig. S6) and between Thailand and Cambodia samples.
For summarizing the impact of a genetic signature, one often stratifies patients to demonstrate separation between class-defined survival curve estimates.
The results at 36 days demonstrate separation between dosing cohorts with respect to percent change in hs-CRP and achieved statistical significance at the highest dose, with a 76.7% reduction in hs-CRP in the ISIS CRPRx 400 mg arm compared with a 14.4% reduction in the placebo arm at Day 36 (P = 0.0015).
It is not surprising that the authors were able to demonstrate separation of the survival curves between high ligand expressers and low ligand expressers because AREG and EREG were chosen as biomarkers post-hoc.
But more often they're used to demonstrate separation — a problem that "Show Boat" courageously highlighted.
On the microscopic scale, fluorescence imaging of prostate and tumor tissue histology slices also demonstrated clear separation between tissue types.
When considering overall survival and disease-free survival, the original data demonstrated clear separation between the two groups based on risk of breast cancer recurrence.
Differences in PDI-4 summed subsection severity scores between such patient cohorts were much smaller, though the PDI-4 scores still demonstrated statistical separation between patients with and without a particular diagnosis in all cases.
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