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However, as we also demonstrated sensitization and activation (pharmacological effects) of MCs during immediate (type 1) hypersensitivity reactions in normal animals occurred after 9 12 days of repeated ocular challenges [4 8, 100].
On experimental day 38, all three MDMA groups demonstrated sensitization to MDMA in at least one locomotor index.
We have recently demonstrated sensitization of docetaxel treatment by EphA2 siRNA in a murine model of human ovarian cancer [ 38].
To date, a multitude of publications has demonstrated sensitization of cancer cell lines to TRAIL-induced apoptosis.
They used the conjugate to deliver MDR1-specific siRNA, and demonstrated sensitization to doxorubicin treatment of the otherwise resistant MCF-7 cells.
We thus demonstrated sensitization to TRAIL within a population of tumor cells, if a fraction of those cells commits to therapy-induced senescence.
Similar(53)
Therefore, the XRD results along with EDAX spectrum analysis demonstrate sensitization of SnO2 qualitatively using CBD.
However, animals pretreated with 3 high doses (24-h apart) of amphetamine (14 mg/kg IP) or apomorphine (40 mg/kg SC) did demonstrate sensitization to a lower test dose of amphetamine (7 mg/kg IP) or apomorphine (3 mg/kg SC) when placed in an environment that was different from the pretreatment environment.
However, animals pretreated with three high doses (24 h apart) of amphetamine (14 mg/kg, IP) or apomorphine (40 mg/kg, SC) did demonstrate sensitization to a lower test dose of amphetamine (7 mg/kg, IP) or apomorphine (3 mg/kg, SC) when placed in an environment that was different from the pretreatment environment.
Three participants demonstrated questionable sensitization reactions and underwent a rechallenge; none of the participants displayed conclusive contact sensitization.
A study in colon cancer cell lines [46] showed that the DAC inhibitor sodium butyrate also caused substantial decrease in c-FLIP protein concurrent with TRAIL sensitization, although similar studies in several hematological cell lines using sodium butyrate and vorinostat demonstrated TRAIL sensitization without reduction of c-FLIP [34].
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