On the other hand, because of the demonstrated role of carboxylesterases in (pro drug metabolism, the risk of undesirable drug-drug interaction should also be considered.
The known immunosuppressive effect of corticosteroid use coupled with the demonstrated role of immunosuppression in the development of sepsis following orthopedic trauma necessitates further studies examining this topic [17, 37, 52].
Abad et al. screened seven small molecule compounds with a demonstrated role in iPSC reprogramming and found that the Notch inhibitor DAPT enhances GHMT transcription factor cocktail reprogramming (Abad et al., 2017).
This is justified by the demonstrated role of the microtubules in the force generation.
These results are consistent with the previously demonstrated role of ATF3 on ER stress induced apoptosis in islets [14], [25].
Furthermore, loss of MAGI-1 has additional effect on neuronal plasticity besides the demonstrated role in non-associative learning [21].
Beyond its demonstrated role in herpesviruses, Arg is also common in a tornovirus recently found in Florida turtles with FP [63].
Rad52 is the central HR protein in budding yeast, playing a demonstrated role in almost all Rad51-dependent and –independent HR [3], [4], [5], [66].
Furthermore, although starch accumulates during cold acclimation we show it is still degraded at night, indicating significance beyond the previously demonstrated role of maltose and starch breakdown in the initial phase of cold acclimation.
These results are in accordance with the demonstrated role of MARCKS in the formation of protrusions and dynamic adhesions [27] and are observed in Sbcl2 and Wm1361 melanoma lines as well as Wm266.4 (Fig. S4).
Our data, showing a localized interaction between osk and Staufen near the posterior, is able to reconcile the role of Staufen with its demonstrated role as a translational activator.
