Using deletion constructs, Ostermeyer et al. [ 26] demonstrated requirement of a hydrophobic domain for lipid droplet targeting of caveolin-1.
Gene deletion experiments in mouse have clearly demonstrated requirement for Tbx5 and Tbx4 to establish the Fgf10-Fgf8 positive feedback loop between the limb mesenchyme and overlying ectoderm.
It is important to note that none of these ideas is inconsistent with the demonstrated requirement for α'/β' activity during the post-training consolidation period.
Thus, reduced hippo signaling and pS127-YAP levels appear effectively uncoupled from automatic nuclear localization, in keeping with the recently demonstrated requirement for tyrosine phosphorylation to mediate the transition [ 29].
Instead, we demonstrate requirements for IRF4 and MDM2.
Our results demonstrate requirements of extracellular calcium and TRPC channels in BDNF responses, a perspective also supported by other recent studies [44], [45].
Together, these observed phenotypes demonstrate essential requirements for stable H+ efflux in normal craniofacial development, osmotic balance, and tail regeneration.
In keeping with its expression patterns, tmem33 knockdown demonstrated a requirement for tmem33 during normal angiogenesis and pronephric development.
Experience with assembling the bombs convincingly demonstrated the requirement, in Sandia if not in Washington, for a much larger unit.
Recent studies have demonstrated its requirement at many steps of eye development.
