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Of significance, PCR analysis clearly demonstrated replacement of mtDNA in HeLa p cells following mitochondrial transplantation.
In this paper, we demonstrated replacement of an approximately 100 kb DNA segment of the M. mycoides genome with a synthetic DNA counterpart in two orientations.
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These changes are readily appreciated on peripheral blood smears, which demonstrate replacement of the anisopoikilocytosis of the baseline phenotype with a relatively monotonous population of evenly sized and shaped hypochromic microcytes (Fig. 2D).
The majority of patients (45, 42%) possessed the heterozygous genotype, 30 patients (28%) showed no C → T substitution, and 31 patients (29%) demonstrated a replacement of C by T for both alleles.
Rahman et al. demonstrated that replacement level fertility has almost been achieved in women who are better educated and socioeconomically better off, while replacement level fertility has not been achieved yet for the less well-off [ 9].
The simulation results demonstrated that replacement of C3 with CO2 in the solvent mixtures has led to the recovery of the same amount of oil.
Moreover, the cell-based investigation demonstrated that replacement of the linker C4 chain with another alkyl chain (C6 or C8) gave rise to the enhancement of cytotoxicity.
The present work demonstrated that replacement of the chroman ring of ANS-118, a commercial insecticide, with chromanone moiety could result in new compounds with high potent insecticidal activity.
Allen et al. [12] demonstrated that replacement of phenylalanine residue (F) with alanine (A) in this C-terminal region impairs the PP1-binding activity of Phactr1.
Most tumor-positive lymph nodes in the control group (78%) demonstrated complete replacement of the normal lymph node architecture with tumor cells.
This study demonstrated that replacement of hydrophobic Val68 by charged and polar residues led to substantial changes in the reduction potential of the heme iron.
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