Sentence examples for demonstrated potency in from inspiring English sources

For instance, sunitinib (SU), an anti-angiogenic TKI that target the VEGF receptors (VEGFRs), repeatedly failed in multiple phase III clinical trials and preclinical models of advanced metastatic breast cancer, whereas, in contrast, it demonstrated potency in inhibiting angiogenesis-dependent growth of primary breast tumors in preclinical models (Abrams et al, 2003; Guerin et al, 2013).

Even in the susceptible BALB/c mice, the gp63 DNA vaccination demonstrated potency and durability against experimental VL.

Compounds 5p and 33b demonstrated high potency in inhibiting SGLT2 and high selectivity against SGLT1.

Although preclinical studies demonstrated their potency in inducing antitumor immunity, several bottlenecks hinder the broader application of mRNA vaccines.

The hydroxy-substituted inhibitor 10 demonstrated high potency in genotype 1a and 1b replicon and in the panel of HCV protease mutants.

Compounds 7e, 14b and 16 demonstrated high potency in decreasing nicotine-evoked [3H]dopamine release (IC50 = 2.2, 46, and 107 nM, respectively).

In this respect, it is worth mentioning that Tipranavir, although considered one of the most potent inhibitors, demonstrated lower potency in our assay.

Against W1L2 cells, CB300179 and CB300189 demonstrated reduced potency in the presence of exogenous thymidine (dThd), and against a W1L2 C1 TS overproducing cell line.

All three antibodies, irrespective of epitope specificity, demonstrated comparable potency in the RF-ADCC assay to Abs A32 and C11 — two Abs identified as the most potent ADCC Abs in a study of 41 CD4i-specific Abs (Guan et al., 2013).

These data show that in contrast to polyanion polymers [18], [19], SPL7013 demonstrates similar potency in the inhibition of X4 and R5 strains of HIV-1.

Apart from their defensive naivety during the 4-1 defeat by Russia, Czech Republic's other failing was waiting until late in the game to demonstrate their potency in attack.