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Several studies [ 23- 25, 28] demonstrated post -duplicational relaxation of purifying selection in paralogs.
Epitope-mapping experiments indicated that among the subjects who demonstrated post -exposure antibodies to romiplostim, 70% were directed toward the TMP peptide, the active site of the molecule.
Significant improvement in clinical outcomes, including VAS neck, VAS arm, JOA and NDI scores, were demonstrated post -operatively for both the arthroplasty and the ACDF groups.
As we have also demonstrated, post -transcriptional modifications can affect the equilibrium distribution of unfolded, partially folded, and native species in tRNA.
Similar changes in the dorsal horn have been demonstrated post -mortem in human subjects who had suffered from post-herpetic neuralgia [ 125].
The elevated aspartate transaminase and alanine transaminase levels observed at baseline in our patients might indicate a history of liver abnormalities, particularly nonalcoholic fatty liver disease, for which a significant reduction has been demonstrated post -surgery.
Myelin production is itself stimulated by axonal activity [Demerens et al., 1996] so abnormal neuronal functional activity may be reflected by changes in myelin patterning [Fields, 2005], something demonstrated post -mortem in adults with autism [Zikopoulos and Barbas, 2010].
Quantitative analysis of the white matter demonstrated post -revascularisation improvement in CVR in the MCA territory of the intervened hemisphere (−0.032±0.023 to 0.059±0.007, p<0.05, Wilcoxon matched-pairs signed ranks test) but not in the non-intervened hemisphere (0.026±0.025 to 0.073±0.008, p<0.05, Wilcoxon matched-pairs signed ranks test).
In our previous work that demonstrated post -translational modifications of maternal proteins, we used a similar approach to perform large-scale protein identification in mature mouse oocytes, and we successfully identified a total of 380 different proteins corresponding to 869 proteins spots [ 17].
To illustrate this point, figure 3 presents information from the NVivo analysis showing the factors that were influential for individual studies with different attributes as follows: cases 1 and 12, both with significant results, published and demonstrated post -study impacts; case 21 with significant published results but no impact; and case 32 with non-significant published results and no impact.
In some instances, promoter:reporter constructs have been used to identify cis-regulatory regions that are required for imprinting [ 19, 30], while only one study has demonstrated post -fertilisation nascent uniparental de novo transcription of an imprinted gene in the endosperm [ 17].
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The phrase "demonstrated post " is intended to function as a descriptor, indicating something that has been shown or validated following a specific event or publication. However, it's not a standard construction, as Ludwig AI indicates. Rephrasing is generally advisable for clarity.
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