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Binding of VEGF-D to VEGFR3-765, for example, was demonstrated only when the assay was performed in solution.
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However, this association was demonstrated only when either the Polish or the Russian groups were analysed separately, and was abolished when the two cohorts were combined.
In vitro models suggest schedule-dependent cytotoxic interactions for the combination of thymidylate synthase inhibitors with SN-38 and L-OHP; indeed, synergistic effects were demonstrated only when SN-38 was started 24 48 h before the L-OHP/5-FU/LV exposure in WIDR and SW620 human CRC cell lines (Fischel et al, 1999).
He thinks that a true understanding of the processes involved will be demonstrated only when it is possible to build a simulation that does exactly but artificially what happens in nature.
Moreover, in more recent meta-analyses positive results favouring NAC are demonstrated only when they include published trials.
Furthermore, fluid-phase FB activation was demonstrated only when pro-FD was activated with trypsin [ 28].
The functional consequence of the heterogeneous surface expression of CTLA-4 was demonstrated only recently when highly activated proliferating T cell populations were separated on the basis of surface CTLA-4 expression and restimulated [ 11].
Leptin demonstrated a decline only when the exercise energy deficit was >800 kcal (11).
The good was demonstrated only moments later, when Eliza Peterson, 6, saw her kindergarten teacher from last year walking down the hill toward the playground.
Taken together, a new model for the role of SNF in Sxl autoregulation can be readily proposed based on our results along with previous study results: It has been demonstrated that SNF functions only when the "master switch" protein SXL does not have a strong presence and the whole auto-regulation system needs a "jump-start" [43].
However, these approaches have been demonstrated to be effective only when the viral vectors or enzymes are supplied directly to the diseased brain.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com