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He thinks that a true understanding of the processes involved will be demonstrated only when it is possible to build a simulation that does exactly but artificially what happens in nature.
Moreover, in more recent meta-analyses positive results favouring NAC are demonstrated only when they include published trials.
Furthermore, fluid-phase FB activation was demonstrated only when pro-FD was activated with trypsin [ 28].
Binding of VEGF-D to VEGFR3-765, for example, was demonstrated only when the assay was performed in solution.
However, this association was demonstrated only when either the Polish or the Russian groups were analysed separately, and was abolished when the two cohorts were combined.
In vitro models suggest schedule-dependent cytotoxic interactions for the combination of thymidylate synthase inhibitors with SN-38 and L-OHP; indeed, synergistic effects were demonstrated only when SN-38 was started 24 48 h before the L-OHP/5-FU/LV exposure in WIDR and SW620 human CRC cell lines (Fischel et al, 1999).
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The functional consequence of the heterogeneous surface expression of CTLA-4 was demonstrated only recently when highly activated proliferating T cell populations were separated on the basis of surface CTLA-4 expression and restimulated [ 11].
The good was demonstrated only moments later, when Eliza Peterson, 6, saw her kindergarten teacher from last year walking down the hill toward the playground.
Although familial aggregation with disease has been demonstrated since the first modern description of HCM in the late 1950s, the genetic basis was definitely demonstrated only in 1989, when linkage analysis revealed an association between HCM and a locus on chromosome 14q1.
The MMSE, one of the most commonly used cognitive screening tools, demonstrated only fair agreement and poor sensitivity when compared to concurrently administered neuropsychological test batteries in acute respiratory failure survivors during their first year of recovery.
This is especially evident when distant protein relationships are demonstrated only with three-dimensional structures.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com