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Bortezomib, a proteasome inhibitor, has demonstrated objective responses in patients with BAC in early-phase clinical trials.
He also demonstrated objective improvements in his cervical motion.
After Tx, 59 of 77 snorers (76.6%) reported improvement in snoring, 77.1% of patients with obstructive sleep apnea reported improved PD, and 2 of 3 retested patients with obstructive sleep apnea demonstrated objective improvement in sleep study apnea-hypopnea index.
Neither study with mTOR inhibitors demonstrated objective responses or disease stability.
In addition, the platform has demonstrated objective safety, with no detrimental effects observed on outcome parameters.
This treatment has demonstrated objective response rates of 25 29% with minimal toxicity as compared to standard regimens [ 9- 11].
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Out of the 50 largest school districts in the United States, only three districts specifically require teachers to demonstrate objective student growth on standardized tests prior to being awarded tenure during the 2007 2008 school year, according to the NCTQ Teacher Contract Database.
Similarly, patients treated with dacarbazine alone typically demonstrate objective disease progression on the first restaging scan (e.g. Chapman et al, 2011).
One single-agent study with gemcitabine at 1200 mg m−2 days 1, 8 and 15 q 4 weeks, failed to demonstrate objective response in 23 patients (Smorenburg et al, 2001).
Unlike a previous study reporting larger changes in VEGF levels in pts demonstrating objective tumour responses during sunitinib treatment (Deprimo et al, 2007), we observed that the magnitude of increase in VEGF levels under treatment was associated with OS (P=0.02).
Initial clinical studies using MA at 160 mg day−1 in 46 and 11 patients, respectively, did not demonstrate objective tumour response (Colleoni et al, 1995; Chao et al, 1997).
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