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The combination product demonstrated numerically greater improvements for a number of the secondary endpoint evaluations versus all three of the comparators, with many endpoints meeting the criteria for statistical significance as per the sequential gatekeeping approach.
Patients who achieved clinical remission demonstrated numerically greater improvements in physical function, especially versus patients in MDA/HDA, regardless of the index used, supporting an association between early suppression of inflammation and long-term functional benefit.
Patients naïve to BDMARD therapy demonstrated numerically greater clinical responses when compared with patients who had experienced prior BDMARD therapy, although both subgroups were associated with significant improvements from baseline.
Disease control, as evaluated by asthma control days, rescue medication-free days, symptom-free days, and awakening-free nights (Table 3), demonstrated numerically greater improvements for fluticasone/formoterol compared to all the comparator treatments.
Asthma symptoms, as evaluated by rescue medication use, asthma symptom scores, and sleep disturbance scores, recorded daily by the patients, demonstrated numerically greater improvement for those administered fluticasone/formoterol compared to the individual components and placebo.
Calculation of effect sizes demonstrated numerically greater efficacy of rivastigmine versus placebo on each of the subscales, and a broad range of SIB items; greatest effect sizes were observed on SIB items assessing the current month (effect size = 0.30) and digit span series (effect size = 0.33).
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The wavelength discrimination of the designed structure is demonstrated numerically.
This mechanism, as well as a high potential for multistability, is also demonstrated numerically for a coupled pair of Hodgkin-Huxley neurons.
The convergence of the method is demonstrated numerically.
Convergence of the Godnuov-type method is demonstrated numerically.
This phenomenon is studied asymptotically in the sense of the Chapman-Enskog expansion and demonstrated numerically.
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