Sentence examples for demonstrated most likely from inspiring English sources

However, clinical efficacy of HDACi, particularly in solid tumors, remains not demonstrated, most likely because of lack of understanding of the best context and combination regimen for their clinical use.

These data demonstrate the most likely site of infection for the 4 HFRS patients.

The three alternative splice forms analysed so far (p150-Δ5; p150-Δ5,6: p150-Δ5,6,7) alshowedwed a tissue specific expression pattern [ 58] demonstrating that most likely only a limited number of different dynactin1 subunits and not all possible combinations are present in a single cell.

We then studied the time-dependent evolution of the optical absorption of Cu3- x P NCs in the NIR, which was supportive of a LSPR, as first reported by Pradhan et al. Our studies demonstrate that most likely both the p-type metallic character and the presence of a LSPR in the NCs stem from the thermodynamically favored substoichiometry in Cu.

It is demonstrated that the most likely explanation for the effect is the impact of stress from the metal film on the silicon resistance.

The functional consequences of methylphenidate-induced molecular changes in the direct pathway remain to be demonstrated, but are most likely related to the corticostriatal circuits/functional domains affected by this drug.

This is justified on the basis of the models of [25], who demonstrated that a most likely cause of the environmental variation is determined by the cost of minimising variability during development.

Similar PASTA investigations demonstrated that the most likely pairing in the N-terminal region was an antiparallel β-sheet for residues 8 11, with a lower self-aggregation and a higher energy of −5.33 than the corresponding most likely pairing in the C-terminal domain.

These data demonstrated that protamines most likely did not contribute to the chromatin defects in Bscl2−/− late spermatids and sperm.

Synteny data demonstrated that the most likely scenario for the increased size of gene families are two consecutive rounds of genome duplication, the so-called 2R-hypothesis [ 10- 12].

Our findings on the regulatory network on the one hand extended the known functions controlled by SigH, and on the other hand demonstrated that stress most likely imposes further actions that modulate the transcriptional control of apparently stress-related or unrelated genes.