Exact(2)
The C7-epimer 12 caused negligible inhibition of HDAC activity, failed to induce global histone 3 (H3) acetylation in the HCT116 colorectal cancer cell line and demonstrated minimal effect on growth.
Similarly, analogue 16a with d-1-naphthylmethyl side chain at C2 too had negligible inhibition of HDAC activity, failed to induce global histone 3 (H3) acetylation in the HCT116 colorectal cancer cell line and demonstrated minimal effect on growth.
Similar(57)
Prior studies using SDS have demonstrated minimal effects on CJD infectivity [ 16], but up to a 3 log10 reduction on scrapie infectivity [ 17].
Supplementing crystalloid fluids with albumin also did not alter circulating neutrophil, monocyte, or lymphocyte counts, which suggests that systemic leukocyte recruitment is unaffected by albumin, and is consistent with the data from our intravital microscopy experiments demonstrating minimal effects of albumin on hepatic leukocyte recruitment.
The SF-36v2 scales demonstrated minimal floor effects and ceiling effects were noteworthy only for the role-physical, social functioning, and role-emotional scales.
It has also demonstrated minimal ceiling effects (within pre-injury scores only), and no floor effects.
Additional toxicology studies employing NSF mice xenotransplanted with the therapeutic cell product demonstrated minimal untoward effects.
The procedure with increasing ΔK demonstrated minimal interaction effects and hence it is recommended for efficient FCG data generation.
NDs demonstrated minimal antimicrobial effects at any time point (Fig. 2 B, C).
In vivo studies using rats exposed to EPFRs containing particles demonstrated minimal adverse pulmonary effects.
The questionnaire demonstrated minimal floor and ceiling effects with no more than 5% of respondents having minimum (floor effect) or maximum (ceiling effect) scores for all scores.
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