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For example, NAA at all locations except the pons, creatine in the LCWM, and choline in the white matter (LCSO and LCWM) all demonstrated large changes in metabolite T2 with age.
Previous structural data of allosterically inhibited caspases demonstrated large changes in the active site loops, particularly in loop 3, which forms the base of the substrate-binding pocket [ 1, 3, 7].
Detailed analyses of variations obtained in expression profiles of the studied brain regions of Goto-Kakizaki rats demonstrated large changes in the hippocampus and prefrontal cortex, as 266 versus 147 probes were found to be differentially expressed, respectively, as compared to Wistar controls.
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Firstly, although the experimentally measured void fraction profiles demonstrated large changes along the radial direction, the changes in the velocity profile shape were comparatively very small for different θ.
Change in domain scores of the PedsQL™ again demonstrated that physical and school functioning scores were preferentially affected among subjects with prolonged fever, prolonged functional impairment, and with non-scheduled return to healthcare; subjects with prolonged fever and non-scheduled return to healthcare particularly demonstrated large negative changes in these domains (Table 5).
Interestingly, these experimental manipulations of SR properties also demonstrated that large changes in Ca2+Mg2+-ATPase activity occurred in the absence of changes in membrane unsaturation [13], [14].
Namely, those genes in common between the two analyses (common and per-gene variance assumption) generally demonstrated very large changes in expression levels while having small variances.
These results show that 812 genes exhibit log2 ≥ 1.5-fold changes in expression over a 96 hour cyst induction period demonstrating large global changes in gene expression during cyst development.
Additionally, a meta-analysis of effective interventions demonstrated medium to large changes in intention, followed by small to medium effects in changing behavior [ 60].
Chan et al. demonstrated a large change in preoperative plans with the addition of CT scans to plain radiography.
Structural dynamics theory predicts and scale model experiments have demonstrated that sudden, large changes in structure properties caused by moment connection fractures will cause transient dynamic response.
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