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Recent studies have demonstrated its requirement at many steps of eye development.
Genetic inactivation of DMRT1 demonstrated its requirement for the development of the male gonad [27], but did not lead to sex reversal in XY mice, suggesting the involvement of additional interacting factors in order to phenocopy the human phenotype.
Several gene products have been shown to influence somatic homolog pairing in flies; for example, experiments using dsRNAs and chemical inhibitors targeting Topoisomerase 2 (Top2 ) have demonstrated its requirement for normal pairing of homologous euchromatic sequences in cultured Drosophila cells (Williams et al. 2007).
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We focused on mir-71 which when mutant led to robust and significant lifespan phenotype, demonstrating its requirement for a normal long life.
These findings identify Tiam1-Rac signaling as the first antagonist of centrosome separation during prophase, demonstrate its requirement in balancing Eg5-induced forces during bipolar spindle assembly in vitro and in vivo, and show that proper centrosome separation in prophase facilitates subsequent chromosome congression.
Out of the three professionally-administered instruments included in our review, the PNAT is the only instrument which had demonstrated its low training requirement for professionals to complete in an experimental design study.
Dietary Br deficiency is lethal in Drosophila, whereas Br replenishment restores viability, demonstrating its physiologic requirement.
The study revealed that mutation of Lys487 resulted in ∼95% loss of the activity thus demonstrating its crucial requirement for the enzymatic activity.
Slush nitrogen's usefulness has been demonstrated by its requirement for the successful cryopreservation of insect embryos.
By making research a requirement, the school demonstrates its devotion to making sure students are proactive in their fields.
Davies added: "An armed police officer is a uniquely complex role and this case demonstrates that its requirements go beyond a person's capability to make a split-second decision in a life-threatening situation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com