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The gangliosides GD2 and GM3 secreted by human and murine neuroblastoma cell lines have been shown to inhibit differentiation of DC from CD34+ progenitors; the gangliosides GM3 and GD3, secreted by human melanomas, have been demonstrated inhibit DC differentiation from monocytic precursors.
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These findings demonstrated inhibiting autophagy together with PA-MSHA might be a promising therapeutic strategy in treating hormone receptor negative breast cancer cells.
In contrast, in-vitro and in-vivo studies demonstrated inhibited tumor cell proliferation by downregulation of Her4 expression or deactivation of Her4 function upon Her4 targeting [ 22- 24].
As a result of the performed research, 18 novel compounds were designed, synthesized, and tested in experiments, and two of them have demonstrated inhibiting activity ~10 μM.
Recently, NAC has been demonstrated to inhibit apoptosis [ 5, 6], possess anti-inflammatory activities [ 7] and inhibit proliferation [ 8].
HIF-1 α induction was demonstrated to inhibit c-Myc transcriptional activity and suppress cell proliferation.
Some of these constituents have also been demonstrated to inhibit STAT3 signaling in different types of tumor cells23, 25.
Cytokeratin 8 (CK8), together with its heterodimeric partners CK18 and CK19, has been demonstrated to inhibit MHC I interactions with TCRs on CD8+ CD8+73.
The best of the obtained compounds demonstrated to inhibit Syk-kinase activity at IC50 = 230±10 nM.
It has recently been demonstrated to inhibit tumor progression and metastasis in in vivo models.
In this study, Zeocin (400 μg/ml) was demonstrated to inhibit the growth of C. rugosa.
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