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Hepatic histological analyses demonstrated indications of simple steatosis in rats induced by an 8-week high-fat diet, and a high-fat diet for 12 weeks and 16 weeks could induce steatohepatitis (NASH) in rats.
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Although these approaches have demonstrated tantalising indications of efficacy in a small group of individuals, they have not reached the threshold of therapeutic efficacy or safety.
A possible solution to this dilemma is to design proof-of-concept studies to explore whether a therapy demonstrates consistent indications of a possible clinical benefit for multiple endpoints that are relevant to the disease.
Radiographic examination demonstrated no indication of screw bending or displacement.
Other studies have demonstrated the indication of asymmetric IgG synthesis by a progesterone induced blocking factor (PIBF) [ 16].
Here we have demonstrated clear indications that, in the specific case of H3N2, the virus has undergone increasing positive charge since its introduction in humans.
This study has demonstrated the first indication of a genetic basis to atrophic jawbone resorption.
A specific connection between p53 and phospholipid metabolism was demonstrated previously with indication of feedback regulation between phospholipid turnover and p53 activity [ 52- 55].
This is in contrast with recent observations by Novak and co-workers, where a prominent diastolic calcium rise was demonstrated as an indication of DADs.
In the future, diagnostic tests may be used to select individuals who are likely to benefit from treatment or those who demonstrate an objective indication of treatment efficacy.
Mean PSA doubling time significantly increased with treatment from 15 to 54 months, demonstrating a good indication of a relationship between the consumption of pomegranate juice and prostate health.
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