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In a different setting, contact-dependent activation of STAT3 has been also demonstrated in normal and cancer breast cells.
Likewise, activation of mtNOS and enhanced mitochondrial NO levels were previously demonstrated in normal rat development, hypothyroidism, cold acclimation, and hypoxia [14] [16].
However in these disorders the symptoms paradoxical responses to sensory stimuli that are not consciously perceived are associated with structural brain lesions (although subliminal awareness may also be demonstrated in normal subjects by manipulating stimuli under experimental conditions [22]).
A similar antagonism has been demonstrated in normal and DM1 myoblasts between the complex made of hnRNP H and CUG-BP1, and MBNL1, during exon 11 selection in IR splicing [22].
Entrainment has been robustly demonstrated in normal humans during wakefulness or non-REM sleep or under anesthesia [19], [21], and to some extent in subjects after lung transplant [22] suggesting that other respiratory-related afferents (such as those from the chest wall) may be recruited after vagotomy to maintain entrainment.
This has also been demonstrated in normal cells forced to have a double complement of DNA and centrosomes: retinal pigmented epithelial (RPE1) cells treated with a cytokinesis inhibitor are able to cluster the centrosomes to form a bipolar spindle and proceed through the cell cycle [4].
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However, this was demonstrated in normal-weight healthy subjects or lean subjects with type 1 diabetes in studies assessing small subcutaneous injections (i.e., 4 12 units) (2– 4).
Significant changes with age were demonstrated in clinically normal, neonatal pigs (Group 1), including an increase in B-cells and T-cells, and an increase in the proportion of total T-cells expressing MHCII.
SRIF production has been demonstrated in the normal ovaries of many species, but in the human ovary it has only been demonstrated in follicular fluid to date (Holst et al, 1994).
This finding is in keeping with those found in colorectal and oesophageal cancer where survivin expression was demonstrated in adjacent normal tissues (Sarela et al, 2000; Kato et al, 2001).
Using RT-PCR, the presence of mRNA that encodes full-length or rodless plectin was demonstrated in the normal human control as well as in the proband's cultured fibroblasts (Fig. 1B, 6).
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