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Both groups demonstrated improved functioning at one-year follow-up, but fewer dropouts had a successful outcome (34.5% vs. 59.1%) and their recidivism rate was significantly higher (62.9% vs. 28.9%) even after controlling for baseline differences.
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A recent longitudinal study demonstrated improved function and a decrease of pain in patients with LSS, without receiving any surgical intervention [ 36].
Patients treated primarily with surgical therapy often demonstrate improved function over time as healing progresses, the scar tissue softens, sensory recovery proceeds, and patients adapt compensatory strategies.
Those patients who survived demonstrated improved microvascular function during the first few days of hospitalization, while no improvement in microvascular dysfunction was seen with time in non-survivors [ 13].
Cells cultured as MCAs also demonstrated improved cell functions than the cells cultured in 2D monolayer.
The move was unprecedented because the decision was based not on clinical trials impractical given the small number of patients with these rare mutations but on lab studies that demonstrated improved chloride function in cell lines engineered to carry such mutations.
Patients who were randomized to CsA withdrawal had superior graft and patient survival, demonstrated improved renal function, better blood pressure control, and a lower rate of skin and nonskin posttransplantation malignancy.
Patients who received donepezil also demonstrated improved global function, as measured by CIBIC-plus.
Atacand was discontinued and 3 weeks later renography (Fig. 2) demonstrated improved renal function: total estimated GFR 47 ml/min.
Similarly, exendin-4-treated mice demonstrated improved systolic function post-MI, reflected by higher ejection fraction and lower LVESV.
Case series have demonstrated improved nerve function in up to 88% of ambulatory patients after 40 mg prednisolone daily for 12 to 20 weeks.
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