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In this context, the model arising from the current data is one where the previously demonstrated gradient of β-cell dysfunction associated with gestational dysglycemia (4) is mirrored by a gradient of chronic progressive deterioration of β-cell function over time that will ultimately lead to the manifestation of long-term diabetic risk.
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Son et al. (2012), using microarray technology, also demonstrated gradients of gene expression in the adult and developing mouse cochlea, a subset of which (approximately 5% of those genes assayed) exhibited clear spatial and temporal variations in expression along the cochlear duct.
Line scans (Fig. S2c,e) show relative counts signal and were extracted from map data to demonstrate gradients of element composition along a chosen transect in the samples.
Frames taken from a movie show talin FRET ratio (FRET emission/acceptor intensity) demonstrating gradients of tension withing single focal adhesions, adhesion formation, sliding and disassembly.
Taking advantage of high-resolution diffusion-weighted sequences, we demonstrate gradients of connectivity to motor, associative, and limbic cortical regions, spanning along the entire length of the STN.
Furthermore, we demonstrate gradient-driven chemotaxis of platelets by video microscopy and transwell migration toward formyl peptides.
It demonstrated a gradient of UHg concentrations with the distance from the pollution sources.
Northern analysis using a set of overlapping probes designed to the MjExp2 transcript demonstrated a gradient of sequence conservation along its length (high to low, from the 5′ to the 3′ end of the coding region), and identified the presence of floral senescence-specific expansins.
Fetuses with growth restriction demonstrated a gradient of reduced body weight with a relative sparing of brain mass.
aFTLD-U demonstrated a gradient of FUS inclusions with greater pathology involving anterior cerebrum relative to posterior cerebrum.
In previous work from this laboratory we have clearly demonstrated the gradient of increasing PTP1B activity towards the perinuclear area (Yudushkin et al., Science 2007).
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