A recent review demonstrated data from multiple studies concerning melanoma and renal cell carcinoma and revealed an overall CR rate of about 7.6% (from further analysis of the reported summarized data).
Evidence from multiple approaches demonstrated that the CNDAC/vorinostat combination stimulated a large increase in cell death, suggesting that this was making a significant contribution to the observed synergy.
Evidence from multiple trials demonstrates the efficacy of prophylactic β-blocker, amiodarone, and corticosteroid administration in reducing the incidence of postoperative atrial fibrillation.
This evidence from multiple systems demonstrates that cytoplasmic activity of ERK/MAPK can clearly occur independently of its nuclear transcriptional function [9], [15] [17], and nuclear restriction of phospho-ERK after cell stimulation with growth factors may be the physiologically normal circumstance in either differentiating or normal differentiated tissues.
Evidence from multiple labs has demonstrated that with age, beta cells show decreased expression of cell cycle activators (e.g., FoxM1 mentioned above) with simultaneous increases in expression of cell cycle inhibitors.
Evidence from multiple animal models demonstrates that testosterone plays a crucial role in the progression of symptoms in spinal and bulbar muscular atrophy (SBMA), a condition that results in neurodegeneration and muscle atrophy in affected men.
Although we used two types of Y-chromosome polymarkers manders andemonstrateded consistent results from multiple analyses, populations from other EC high-risk areas were not included in this study, so we cannot ascertain whether all the EC high-risk populations share a common genetic background.
Reproducibility and robustness of the system were demonstrated using biopsies from multiple donors and a commercial cell source.
Preclinical investigations over 20 years have demonstrated that multiple cell types from several sources can produce anticonvulsant, and antiepileptogenic, effects in animal models of TLE.
A recent study in C. elegans has demonstrated that multiple UTR domains from a single gene group together into discrete modules that operate in a combinatorial manner to repress gene expression [ 68].
