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Without something like gold to back paper money, the dollar has demonstrated frequent and rapid shifts in value--which many fear may lead to a plummet reminiscent of the Great Depression.
This locus was initially discovered due to its linkage with a familial melanoma susceptibility syndrome, and subsequent work has demonstrated frequent loss of functionality of one or both of these genes in a wide variety of sporadic tumors (reviewed in [1]).
We demonstrated frequent chromosomal changes in most of these tumors.
Immunohistochemical analyses demonstrated frequent Aβ immunoreactive plaques and mild amyloid angiopathy.
Genomic analysis demonstrated frequent allelic loss and homozygous deletions (Ohta et al, 1996; Croce et al, 1999).
For more details see Table 4. Recent publications have demonstrated frequent hypermethylation of various genes in urogenital cancers.
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Our study also demonstrates frequent positive CSF FTA-ABS or VDRL test results in HIV-positive patients (60%% in HIV-positive vs 16%% in HIV-negative); however, due to the low numbers in the study, this was not found to be statistically significant.
Open image in new window Fig. 7 A PTG demonstrating frequent pathological conditions of teeth and periodontal (bony supportive) structures: 1. Carious lesions [dentine caries d. 37 distocervically, d. 47 distocervially, 48 occlusally and enamel caries d. 25 mesially (dashed arrows)]; bitewing radiography would be helpful for caries diagnostics.
In this study we demonstrate frequent hypermethylation of the APC and RASSF1A tumour suppressor genes in the majority of parathyroid adenomas.
These species C rhinoviruses (HRV-Cs) have been shown to be highly prevalent, with initial studies demonstrating frequent detection of this species in association with bronchiolitis and other lower respiratory tract disease [9], [12] [14], in asthma exacerbations [9], [14] [16] and otitis media [17].
This is the first study demonstrating frequent DAB2 promoter hypermethylation in human cancer.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com