Sentence examples for demonstrated firstly from inspiring English sources

The proposed method has been demonstrated firstly on a numerical beam and then a set of nominally identical steel plates tested in the laboratory.

Experimental data demonstrated that the inhibition of NF-kB in hepatocytes in vivo promotes hepatocarcinogenesis. Kaeberlein et al. demonstrated firstly the anti-aging effects of Sir2 showing that in Saccharomyces cerevisiae the integration of extra copies of Sir2 extended lifespan up to 30% [12].

Our research demonstrated firstly that the natural phytoestrogen genistein can alleviate the deleterious effect of the most commonly used plasticizer DEHP when administrated prepubertally.

When we studied the regulation of Ank expression by TGF-β1, we demonstrated firstly that ERK 1/2 and p38-MAPKs were activated in our cell culture system.

This was demonstrated firstly by siRNA technology in which knock-down of any of the three caveolae proteins blocked the induced anti-inflammatory phenotype of senescent EC with a concomitant increase in the pro-inflammatory phenotype.

Our data demonstrated firstly that this signaling pathway is activated by APAP in hepatocytes and secondly that PTP1B deficiency mimics the inhibition of GSK3 β or SKF on the downstream mediators of this pathway.

The results reported here demonstrate, firstly, that wavelet analysis is applicable to those systems in which FFT techniques also work.

It demonstrates firstly a far greater renewable potential than the targets set by long term policies, and secondly, the viability of meeting the entire electricity demand projected for 2050.

The objective of this study was to advance this encouraging in vitro work to towards clinical translation, by undertaking a preliminary in vivo study to demonstrate, firstly, that PLGA microspheres could be delivered to the disc and retained for a clinically relevant time frame in vivo; and, secondly, that IL-1ra delivered from these microspheres maintained bioactivity in the in vivo space.

These results demonstrate firstly that the two amino acids R146 and R280 are required for recombination catalysis, and that the reaction observed with wild type IntI1 was due to the intrinsic catalytic capability of the recombinant integrase.

Our findings demonstrate firstly an association between Sasang constitution and FD prevalence.