"PER3's role in mood regulation has never been demonstrated directly before," she says.
This process has been often expected but, to our knowledge, never observed and demonstrated directly for these materials fabricated by different techniques.
Although accumulation of IP3Rs through lateral diffusion in ER-lysosome MCSs has not yet been demonstrated directly, constitutive Ca2+ release mediated by local enriched IP3Rs has been reported on ER-mitochondrial MCSs (Szabadkai et al., 2006; Cardenas et al., 2010).
However, it has not been demonstrated directly whether this increase in synaptic transmission is caused by an enhancement of transmitter release or an increase in the sensitivity of the postsynaptic receptors.
The presence of anti-O12 antibodies in typhoid (9/12 or 75.0% sensitive) and paratyphoid A (22/33 or 66.7%) patients was demonstrated directly using a prototypic TUBEX test designed specifically to detect these antibodies.
Without any post-treatment, series Cu(OH 2 films were demonstrated directly as electrode materials for electrocatalytic oxidation of glucose, and the dependence of their electro-oxidation performances on reaction time was evaluated by electrochemical techniques.
We demonstrated directly the energetic decoupling of PBsomes in vivo in response to the bleaching laser.
The presence of rebounds in vivo has been demonstrated directly by using hyperpolarizing current injections [14].
Immunoblotting reveals MYOC aggregates and activation of the UPR is demonstrated directly with a fluorescent reporter transgene.
However, only for the dinucleotides AA, TT, RR and YY a prominent periodical appearance in natural chromatin DNA sequences could be demonstrated directly by positional autocorrelation (distance) analysis [1], [6] [7].
Although radical pairs with appropriate lifetimes have been detected in AtCry1 [37], and now in the migratory garden warbler, it has still to be demonstrated directly that magnetic fields as weak as the Earth's (∼50 µT) can affect cryptochrome signalling in any species.
