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In contrast to the histology, the gene expression study demonstrated diminution in pro-inflammatory gene expression, with significant reductions in MMP-1 and MMP-3, and smaller reductions in TNFα, IL-1β and IL-6.
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Thus, model cells exposed to both a decrease in [K+]e and a more negative glycocalyceal charge demonstrated a diminution of [Na+] and [K+] gradients and a depolarization of Em with respect to control cells, whereas neither of these maneuvers individually caused depolarization of Em.
Systematic increases in the overload, applied prior to the commencement of the HCF cycles, clearly demonstrated a diminution in the contribution of the HCF cycles to crack growth rates.
This demonstrated marked diminution in parasite burden in brain following immunization, most dramatically for those immunized two times compared to the unimmunized group (Figure 9F, P≤0.001).
Quantitative PCR analysis demonstrated a diminution in cFLIP and an augmentation in FasL mRNA levels in sponges from mice with type 2 diabetes (Fig. 2E).
Specifically, we recently demonstrated the diminution of osteoblastic differentiation on such a modified ECM [12] by using the lathyrogen β-aminopropionitrile (bAPN), an inhibitor of the enzyme lysyloxidase (Lox), which extracellularly processes collagen and initiates collagen cross-link formation [13].
The most intriguing findings, however, are the data depicted in Fig. 3Ea e, which demonstrate a diminution in the proliferation (Fig. 3E,a), migration (Fig. 3Eb,c) and tube formation (Fig. 3Ed,e) of SIECs in response to MB-cAMP during the course of diabetes.
We previously demonstrated a marked diminution in plasma NO levels during pregnancy in DBA/J mated CBA/J females when compared to control matings [6].
Our data demonstrated a significant diminution of 45 kDa GLUT3 protein levels by 100 µM METH exposure and protective effect by ALC compared with the control (Fig 4A B).
In that report, Chen et al. demonstrated that a diminution in the expression of cell surface MICL inhibited or augmented cytokine production in a stimulus-dependent manner.
As shown in Figure 1, serial CT scans demonstrated a clear diminution of hepatic vascularity and a smooth contour of the liver.
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