Sentence examples for demonstrated conclusive from inspiring English sources

In recent years, the absence of direct target engagement technologies has manifested as clinical failure of drugs which have not demonstrated conclusive evidence of binding to the intended target2.

Research has not demonstrated conclusive evidence that RF EMF emissions are a cause of adverse or long-term health effects in adults, but studies have shown that these emissions do affect brain activity and sleep patterns in adults.

The comparison of the impact of HES 130 and GEL on oxidative stress and the inflammatory response in hemorrhagic shock demonstrated conclusive protective effects after the HES 130 infusion.

Previous small studies have reported heterozygous SNPs of ATP8B1 in ICP cases (32, 33) but have not demonstrated conclusive functional effects of these variants in in vitro studies (48).

Stem cell transplantation has been suggested as a treatment for myocardial infarction, but clinical studies have yet to demonstrate conclusive, positive effects.

A better understanding of factors associated with low-enrollment sites in clinical trials and the impact on a trial's ability to demonstrate conclusive outcomes may lead to strategies to make trial enrollments more efficient and cost-effective.

We present a specific protocol which eliminates the need for time-consuming and expensive genomic DNA extractions and, using a high-processivity polymerase, demonstrate conclusive screening of samples in <1 h.

This has led to problems in demonstrating conclusive efficacy and in comparing treatments across trials.

Using genetic risk score to combine the effects of risk alleles of these index SNPs did not demonstrate conclusive association with T2D in African Americans [ 46, 49, 50].

While xenografts and cell lines used to create xenografts can demonstrate conclusive assay specificity, they can sometimes behave differently with IHC assays compared with human FFEP tumor tissues because of differences in composition, morphology, and format.

A conservative approach to development of TDM programs is suggested because for many antibiotics, the personnel and resource costs are moderate and studies demonstrating conclusive clinical outcome advantages remain elusive.