In summary, the present study contributes to a better understanding of the regulation of ERBB2 gene expression in breast cancer cells, by demonstrating the implication of Ku proteins together with AP-2 transcription factors in the expression of the oncogene.
In the present study, direct interaction of delphindin with ERα excluding the implication of other factors is demonstrated by the capacity of this compound to exert 73% of specific inhibition against E2 on ERα.
The potential fitness implications of hybridizations were demonstrated by the strong correlation of GRC with admixture proportions, as GRCs directly relate to feeding ecology in whitefish (Amundsen et al. 2004; Kahilainen and Østbye 2006) and are therefore under selection (Præbel et al. 2013a).
The implication of IL-10 in the induction and maintenance of immunosuppression is demonstrated by the reversion of MoDC function upon blockade of IL10-IL-10R IL10-IL-10R IL10-IL-10R
But the high stakes involved were demonstrated by the presence of a Las Vegas gaming commission official monitoring the case because it potentially has implications for the licensing of Adelson's Las Vegas Sands casino empire.
As demonstrated by the case of 6q24-related TNDM, knowledge of the role of imprinting in disease has profound implications for recurrence risks in relatives.
The inhibitory effects of the CB agonist were totally prevented by pretreatment and co-perfusion with the selective CB1 antagonists SR141716A (10 µM, Fig 3B) demonstrating the implication of cannabinoid receptors of the CB1R subtype.
The persistence of refugee status for millions of Palestinians has been the physical bedrock of rejectionism, both expressly, as in the infamous "three noes" of the Khartoum conference of 1967, and by implication, as demonstrated by the recent Palestinian decision to withdraw from direct talks.
